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Advanced Peptide Technology

The matrix is formed from synthetic peptides which are composed of three naturally occurring amino acids in a sequence which is repeated 4 times (Arginine - Alanine - Aspartic Acid - Alanine). The peptides self assemble to form a matrix upon a change in pH caused by exposure to an ions such as Na+ (sodium) or K+ (potassium). Each amino acid, when assembled into a peptide, will take part in creating a specific three dimensional shape. The amino acids are synthesized in a very specific order, and in doing so a very specific shape-forming capability will be programmed into the peptide.

RADA-16 molecule
Mammalian ECM

Mammalian ECM1

Mammalian ECM

PuraStat Scaffold1


The peptides in PuraStat are synthetized in a specific sequence which provide the molecule with shape memory to enable them to self assemble into a scaffold which mimics human extra cellular matrix (ECM). Based on results of scanning electron microscopy, the structure of PuraStat self-assembling peptide hydrogel is understood to be a network of fibres with a diameter of around 10–20 nm and pores with a diameter of about 50–200 nm that resembles the mesh structure of natural collagen.

Dhwani J., Rajesh V. A Review on Extracellular Matrix Mimicking Strategies for an Artificial Stem Cell Niche. Polymer Reviews. 2015, 55:4, 561-595, DOI:10.1080/15583724.2015.1040552
Global, Agile and Local

Global, Agile and Local

Since the inceptions of 3-D Matrix as a spinoff from MIT in 2004, 3-D Matrix has grown to become leading global peptide solutions company headquartered in Tokyo, Japan. With offices serving the Americas, Europe and Asia our employees together with our partners and distributor serve research scientists, healthcare providers and patients around the globe. Learn More »

If you are interested in learning more and getting connected to your local representative, please contact us.

Products from 3-D Matrix


Our accessories are specifically developed with users in mind for both endoscopic and laparoscopic procedures, giving you the full set of accessories that you need for your procedures.

Simply connect the PuraStat syringe with the accessory via the leur lock connector** and it is ready to use.

If you are interested in our accessories or would like more information, please contact us.


PuraStat is a synthetic haemostatic material in the form of a prefilled syringe. PuraStat is indicated for haemostasis in the following situations encountered during surgery, when haemostasis by ligation or standard means is insufficient or impractica1:


PuraBond is a synthetic haemostatic material in the form of a prefilled syringe, filled with a clear, aqueous peptide solution. PuraBond is part of the RADA16 family of products, alongside PuraStat. Contact between the product and liquids such as blood leads to the formation of fibres in the aqueous solution, yielding a peptide hydrogel. The hydrogel quickly coats the point of bleeding and, by physically closing the superficial part of the broken blood vessel, causes blood coagulation in the deeper part of the vascular wall, resulting in haemostasis.


PuraShield is a synthetic haemostatic material for ENT surgery. A ready-to-use, slightly viscous hydrogel, composed of self-assembling peptides (SAPs) founded by the Massachusetts Institue of Technology (MIT), whilst undergoing tissue regeneration research. PuraShield is licenced in Spain as a medical device for use in Ears, Nose, Throat, Head and Neck surgeries.
PuraShield has many advantages which lend it to being a suitable bleeding management solution for FESS, adult tonsillectomies, thyroidectomies and amongst many other types of surgery. PuraShield's composition mimics the human extracellular matrix, and it does not cause swelling of the tissue. Its transparency and viscosity ensure precise control while maintaining visibility during the surgery, even in the event of working in small and narrow spaces.