Clinical Studies

GI Endoscopy and Laparoscopy

Haemostatic efficacy

• de Nucci, G., Reati, R., Arena, I., Bezzio, C., Devani, M., Corte, C., Morganti, D., Mandelli, E., Omazzi, B., Redaelli, D., Saibeni, S., Dinelli, M. and Manes, G., 2020. Efficacy of a novel self-assembling peptide hemostatic gel as rescue therapy for refractory acute gastrointestinal bleeding. Endoscopy. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1145-3412
• Ortenzi, M. and Haji, A., 2020. Safety and feasibility of PuraStat® in laparoscopic colorectal surgery (Feasibility study). Minimally Invasive Therapy & Allied Technologies, pp.1-6. https://www.tandfonline.com/doi/abs/10.1080/13645706.2020.1739711?journalCode=imit20
• Subramaniam, S., Kandiah, K., Thayalasekaran, S., Longcroft-Wheaton, G. and Bhandari, P., 2019. Haemostasis and prevention of bleeding related to ER: The role of a novel self-assembling peptide. United European Gastroenterology Journal, 7(1), pp.155-162. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374844/

Reduction of delayed bleeding (DB) after GI ESD in the colon

• Pioche, M., Camus, M., Rivory, J., Leblanc, S., Lienhart, I., Barret, M., Chaussade, S., Saurin, J., Prat, F. and Ponchon, T., 2016. A self-assembling matrix-forming gel can be easily and safely applied to prevent delayed bleeding after endoscopic resections. Endoscopy International Open, 04(04), pp.E415-E419. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831935/
• Subramaniam, S., Kandiah, K., Fujimoto, A., Yahagi, N., Uraoka, T. and Bhandari, P., 2017. Minimising the risk of delayed bleeding in colonic endoscopic submucosal dissection: Is there a role for a novel haemostatic peptide?. United European Gastroenterology Journal, 5, pp.A1-A160. https://journals.sagepub.com/doi/full/10.1177/2050640617725668
• Subramaniam, S., Kandiah, K., Thayalasekaran, S., Longcroft-Wheaton, G. and Bhandari, P., 2018. Bleeding during Endoscopic Submucosal Dissection: A Randomised Controlled Trial of a Novel Haemostatic Agent. United European Gastroenterology Journal, 6. https://journals.sagepub.com/doi/pdf/10.1177/2050640618792817

 

Cardiac

• Giritharan, S., Salhiyyah, K., Tsang, G. and Ohri, S., 2018. Feasibility of a novel, synthetic, self-assembling peptide for suture-line haemostasis in cardiac surgery. Journal of Cardiothoracic Surgery, 13(1). https://pubmed.ncbi.nlm.nih.gov/29903028/
• Masuhara, H., Fujii, T., Watanabe, Y., Koyama, N. and Tokuhiro, K., 2012. Novel Infectious Agent-Free Hemostatic Material (TDM-621) in Cardiovascular Surgery. Annals of Thoracic and Cardiovascular Surgery, 18(5), pp.444-451. https://pubmed.ncbi.nlm.nih.gov/22986759/
• Morshuis, M., Schönbrodt, M. and Gummert, J., 2019. Safety and Performance of a Self-Assembling Peptide Haemostat for the Management of Bleeding after Left Ventricular Assist Device Implantation: Outcomes of a Post Market Clinical Follow-Up Study. The Journal of Heart and Lung Transplantation, 38(4), p.S194. https://www.sciencedirect.com/science/article/pii/S1053249819304711

Ear, Nose and Throat (ENT)

• Lee, M., Ma, Z. and Ananda, A., 2017. A novel haemostatic agent based on self-assembling peptides in the setting of nasal endoscopic surgery, a case series. International Journal of Surgery Case Reports, 41, pp.461-464. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709301/

 

Haemorrhagic Radiation Proctopathy

• White K. and Henson, C. 2019. PWE-048 Endoscopically-delivered PuraStat for the treatment of severe haemorrhagic radiation proctopathy: A case series. Gut, 68, A195-A196. https://gut.bmj.com/content/68/Suppl_2/A195.2